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B6db families: rubn4

Activity rubn4
Description TDP-3,4-didehydro-2,6-dideoxy-D-glucose aminotransferase (2.6.1.-)
Notes A small family of bacterial enzymes, strictly related to enzymes (such as qdtb and desv) that also produce TTP-3-amino-deoxyhexoses.
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
Sequences in seed alignment
BacteriaDNRJ_STRPE (Streptomyces peucetius); ZP_04032501 (Thermomonospora curvata); EEK34299 (Nocardiopsis dassonvillei); ABV49595 (Streptomyces eurythermus); CAA11782 (Amycolatopsis orientalis); BAC79028 (Streptomyces sp. AM-7161); ACB37737 (Micromonospora chalcea); BAB72037 (Streptomyces galilaeus); AAG13910 (Micromonospora megalomicea); CAI94698 (Streptomyces achromogenes subsp. rubradiris); YP_001537186 (Salinispora arenicola); ACB46490 (Actinomadura kijaniata); CAC48376 (Amycolatopsis balhimycina); AAP85347 (Streptomyces griseoruber);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence CAI94698
Domain interval 13-367
Catalytic site 186 K
 Lamichhane J, Liou K, Lee HC, Kim CG, Sohng JK. (2006) Functional characterization of ketoreductase (rubN6) and aminotransferase (rubN4) genes in the gene cluster of Streptomyces achromogenes var. rubradiris Biotechnol Lett 28 545-53.

 Chen H, Thomas MG, Hubbard BK, Losey HC, Walsh CT, Burkart MD. (2000) Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis Proc Natl Acad Sci U S A 97 11942-7.

Articles on rubn4
last changed 2009/07/23 13:45

B6db families