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B6db families:

uncharacterized family prosc
Activity unclassified
Description unclassified activity
Notes Synonims: YggS (E. coli), FkuA (Vibrio alginoliticus), ylmE (B. subtilis).

The prototype of this family, yeast hypothetical protein YBL036c, is homologous to a P. aeruginosa protein whose gene is co-transcribed with a known proline biosynthetic gene. The structure of the yeast protein shows a covalently bound PLP.

PDB 1B54;
PLP Fold Type III
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type III

Number of sequences
Sequences in seed alignment
BacteriaAAY95028 (Pseudomonas fluorescens Pf-5); NP_899848 (Chromobacterium violaceum ATCC 12472); YLME_BACSU (Bacillus subtilis); BAA09062 (Vibrio alginolyticus); YP_670830 (Escherichia coli 536);
Fungi1B54 (Saccharomyces cerevisiae); CAH02469 (Kluyveromyces lactis); CAB90136 (Schizosaccharomyces pombe);
MetazoaEAW63364 (Homo sapiens); AAA79348 (Caenorhabditis elegans);
ViridiplantaeNP_849649 (Arabidopsis thaliana); CAL50357 (Ostreococcus tauri);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence 1B54
Domain interval 20-249
Catalytic site 49 K
 Ito T1, Iimori J, Takayama S, Moriyama A, Yamauchi A, Hemmi H, Yoshimura T. (2013) Conserved pyridoxal protein that regulates Ile and Val metabolism J Bacteriol. 195 5439-49.

 Eswaramoorthy, S.; Gerchman, S,; Graziano, V.; Kycia, H.; Studier, F.W.; Swaminathan, S. (2003) Structure of a yeast hypothetical protein selected by a structural genomics approach. Acta Crystallogr D Biol Crystallogr. 59 127-135.

 Ikegawa S.; Isomura M.; Koshizuka Y.; Nakamura Y. (1999) Cloning and characterization of human and mouse PROSC (proline synthetase co-transcribed) genes J Hum Genet. 44 337-342.

Articles on
last changed 2014/03/31 16:48

B6db families