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B6db families:

uncharacterized family yhfs
Activity unclassified
Description unclassified activities
Notes Very distinct family of bacterial proteins, built based on Yhfs from E. coli (whose structure is known). Sequences in this family are distantly related to methionine gamma-lyases (family and other C-S lyases, but also to the mocr group of proteins.

Under anaerobiosis, yhfS gene expression is activated by the transcriptional activator FNR. A ΔyhfS mutant has aggravating genetic interactions with genes involved in DNA recombination (source:

The yhfs genes normally cluster together with genes of the yhfx family (see unclassified_family_yhfx). The connection is particularly evident in firmicutes such as Lactobacillus rhamnosum, Jeotgalibaca dankookensis, Carnobacterium sp AT7.

PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences 15
Sequences in seed alignment
BacteriaWP_012859840 (Sebaldella termitidis); WP_062742191 (Enterobacter lignolyticus); WP_005714935 (Lactobacillus rhamnosus); WP_054177853 (Trabulsiella odontotermitis); WP_062532504 (Jeotgalibaca dankookensis); WP_012382302 (Streptomyces griseus); WP_011245531 (Bacillus clausii); P45545 (Escherichia coli); WP_009051932 (Thermoanaerobacter sp. X514); YP_805681 (Lactobacillus paracasei ATCC 334); ZP_03568370 (Atopobium rimae ATCC 49626); WP_049114522 (Klebsiella michiganensis); WP_007723438 (Carnobacterium sp. AT7); WP_043018560 (Citrobacter freundii); WP_078697406 (Caloramator quimbayensis);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence P45545
Domain interval 39-236
Catalytic site 196 K
References Articles on
last changed 2018/02/09 10:49

B6db families