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B6db families: arg.aminomutase

arg aminomutase
Activity arg_aminomutase
Description Arginine 2,3-aminomutase (5.4.3.-)
Notes Arginine-2,3-aminomutase should require a [4Fe-4S] cluster, S-adenosyl-L-methionine (SAM), and pyridoxal-5'-phosphate as cofactors.

The sequence in this family are most similar to L-Lysine aminomutases (5.4.3.2); the prototype enzyme (from S. griseochromogenes) is also substantially active towards L-lysine.

PLP Fold Type VII
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type VII

Reference sequence AAP03121
Domain interval 128-289
Catalytic site 348 K
 
References
 Zhao J, Ji W, Ji X, Zhang Q (2020) Biochemical Characterization of an Arginine 2,3‐aminomutase with Dual Substrate Specificity Chin. J. Chem. 38 in press.

 Cone MC, Yin X, Grochowski LL, Parker MR, Zabriskie TM. (2003) The blasticidin S biosynthesis gene cluster from Streptomyces griseochromogenes: sequence analysis, organization, and initial characterization Chembiochem 4 821-8.

 Prabhakaran P. C., Woo N-T., Yorgey P.S., Gould S.J. (1988) Biosynthesis of blasticidin S from L-alpha-arginine. Stereochemistry in the arginine-2,3-aminomutase reaction J. Am. Chem. Soc. 110 5785-91.

Articles on arg.aminomutase
last changed 2020/04/23 09:13

B6db families