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chdn |
Activity |
chdn |
Description |
9-desmethyl-chelocardin aminotransferase ( 2.6.1.-) |
Notes |
Very small family based on the functionally validated enzyme from Amycolatopsis sulfurea. The closest family in the database is pgat (hydroxyphenylglycine aminotransferase). |
PLP Fold Type |
I |
PLP-dependent Domain |
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Number of sequences |
2 |
Sequences in seed alignment |
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Reference sequence |
AHD25935 |
Domain interval |
68-436 |
Catalytic site |
269 K |
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References |
Lukežič; T, Fayad AA, Bader C, Harmrolfs K, Bartuli J, Groß S, Lešnik U, Hennessen F, Herrmann J, Pikl Š, Petković H, Müller R
(2019) Engineering Atypical Tetracycline Formation in Amycolatopsis sulphurea for the Production of Modified Chelocardin Antibiotics ACS Chem Biol 14 468-477. Lukežič T, Lešnik U, Podgoršek A, Horvat J, Polak T, Šala M, Jenko B, Raspor P, Herron PR, Hunter IS, Petković H (2013) Identification of the chelocardin biosynthetic gene cluster from Amycolatopsis sulphurea: a platform for producing novel tetracycline antibiotics Microbiology 29 2524-32. Articles on chdn |
last changed |
2019/07/31 09:27 |
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