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B6db families: cobc

Activity cobc
Description cobC-like proteins
Notes A family of gene products, similar to CobC from Pseudomonas, apparently involved in the synthesis and addition of aminopropanol, in the cobalamin biosynthetic pathway.

The idea that these proteins are enzymes is strongly supported by the rigorous conservation of the PLP-binding lysine. However, the precise enzymatic function is unknown.

The family has been created because Christen and Mehta, in their reviews on the evolution of B6 enzymes, explicitly cited this group of gene products.

PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences 9
Sequences in seed alignment
BacteriaNP_643497 (Xanthomonas axonopodis pv. citri str. 306); NP_539623 (Brucella melitensis); CAD16100 (Ralstonia solanacearum); AAK88523 (Agrobacterium tumefaciens); CAC46523 (Sinorhizobium meliloti); ZP_00029105 (Burkholderia fungorum); AE004557_6 (Pseudomonas aeruginosa); COBC_PSEDE (Pseudomonas denitrificans); ZP_00051519 (Magnetospirillum magnetotacticum);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence COBC_PSEDE
Domain interval 23-328
Catalytic site 199 K
References Articles on cobc
last changed 2009/07/06 16:31

B6db families