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B6db families: cqsa

cqsa
Activity cqsa
Description Acyl-CoA:L-2-aminobutyrate C-acyltransferase (decarboxylating) (2.3.1.-)
Notes A small family of bacterial enzymes, built based on the validated sequence from Vibrio cholerae. Sequences closely resembling bacterial serine C-palmitoyltransferases (family 2.3.1.50c) amd 8-amino-7-oxononanoate synthases (2.3.1.47).
PDB 2WKA;2WK8;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
12
Sequences in seed alignment
BacteriaZP_00990208 (Vibrio splendidus); EED27463 (Vibrio parahaemolyticus); EDP59323 (Vibrio campbellii); CQSA_VIBHB (Vibrio harveyi); ZP_01385258 (Chlorobium ferrooxidans); EAR21812 (Nitrococcus mobilis); ACD89578 (Chlorobium limicola); NP_232914 (Vibrio cholerae); ACF45719 (Prosthecochloris aestuarii); CAG23609 (Photobacterium profundum); ZP_01866959 (Vibrio shilonii); YP_096734 (Legionella pneumophila);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence NP_232914
Domain interval 39-310
Catalytic site 236 K
 
References
 Jahan N, Potter JA, Sheikh MA, Botting CH, Shirran SL, Westwood NJ, Taylor GL (2009) Insights into the Biosynthesis of the Vibrio cholerae Major Autoinducer CAI-1 from the Crystal Structure of the PLP-Dependent Enzyme CqsA J Mol Biol 393 763-73.

 Kelly RC, Bolitho ME, Higgins DA, Lu W, Ng WL, Jeffrey PD, Rabinowitz JD, Semmelhack MF, Hughson FM, Bassler BL. (2009) The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA Nat Chem Biol 5 891-5.

 Spirig T, Tiaden A, Kiefer P, Buchrieser C, Vorholt JA, Hilbi H. (2008) The Legionella autoinducer synthase LqsA produces an alpha-hydroxyketone signaling molecule J Biol Chem 283 18113-23.

Articles on cqsa
last changed 2009/08/26 14:07

B6db families