B6db families : cysteine

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cysteine desulfhydrase

Activity

Description

Cysteine desulfhydrase (4.4.1.-).

Notes

All the characterized enzymes in this family also show cystathionine beta-lyase activity (E.C. 4.4.1.8) and sometimes methionine gamma-lyase activity (4.4.1.11).
Indeed, the family is tightly related to families 4.4.1.8 and 4.4.1.11, with which it forms a 'supercluster' of C-S lyase enzymes.

PDB

1C7O;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

AAO82584 (Enterococcus faecalis); AAA85439.1 (Treponema denticola); CAD55570 (Corynebacterium glutamicum); NP_940074 (Corynebacterium diphtheriae); AE007794_4 (Clostridium acetobutylicum); BAB07032.1 (Bacillus halodurans); NP_810311 (Bacteroides thetaiotaomicron); CAD30137.1 (Bacillus thuringiensis); NP_268073 (Lactococcus lactis subsp. lactis Il1403); PATB_BACSU (Bacillus subtilis); NP_603522.1 (Fusobacterium nucleatum); BAC20220 (Streptococcus salivarius); CAC92249.1 (Yersinia pestis); BAC00815.1 (Streptococcus anginosus); BAC14294 (Oceanobacillus iheyensis);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

PATB_BACSU

Domain interval

1-380

Catalytic site

234 K

References

Martínez-Cuesta MC, Peláez C, Eagles J, Gasson MJ, Requena T, Hanniffy SB. (2006) YtjE from Lactococcus lactis IL1403 Is a C-S lyase with alpha, gamma-elimination activity toward methionine. Appl Environ Microbiol 72 4878-84..

Auger, S.; Gomez, M.P.; Danchin, A.; Martin-Verstraete, I. (2005) The PatB protein of Bacillus subtilis is a C-S-lyase Biochimie 87 231-238..

Fukamachi, H.; Nakano, Y.; Yoshimura, M.; Koga, T. (2002) Cloning and characterization of the L-cysteine desulfhydrase gene of Fusobacterium nucleatum FEMS Microbiol Lett 215 75-80.

Wada, M., Awano, N., Haisa, K., Takagi, H., Nakamori, S. (2002) Purification, characterization and identification of cysteine desulfhydrase of Corynebacterium glutamicum, and its relationship to cysteine production FEMS Microbiol Lett 217 103-107.

Chu, L.; Ebersole, J. L.; Kurzban, G. P.; Holt, S. C. (1999) Cystalysin, a 46-kDa L-cysteine desulfhydrase from Treponema denticola: biochemical and biophysical characterization Clin Infect Dis 28 442-50.

Rossol, I.; Puhler, A. (1992) The Corynebacterium glutamicum aecD gene encodes a C-S lyase with alpha, beta-elimination activity that degrades aminoethylcysteine J Bacteriol 174 2968-77..

Articles on cysteine.desulfhydrase

last changed

2008/10/23 12:26