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B6db families: cysteine.desulfhydrase.a

cysteine desulfhydrase a
Activity cysteine_desulfhydrase
Description Cysteine desulfhydrase (4.4.1.-). (family a)
Notes All the characterized enzymes in this family also show cystathionine beta-lyase activity (E.C. 4.4.1.8) and sometimes methionine gamma-lyase activity (4.4.1.11).
Indeed, the family is tightly related to families 4.4.1.8 and 4.4.1.11, with which it forms a 'supercluster' of C-S lyase enzymes.
PDB 1C7O;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
15
Sequences in seed alignment
BacteriaBAC20220 (Streptococcus salivarius); NP_940074 (Corynebacterium diphtheriae); CAD30137 (Bacillus thuringiensis); BAB07032 (Bacillus halodurans); AE007794_4 (Clostridium acetobutylicum); BAC14294 (Oceanobacillus iheyensis); CAC92249 (Yersinia pestis); BAH22850 (Prevotella intermedia); NP_268073 (Lactococcus lactis subsp. lactis Il1403); BAC00815 (Streptococcus anginosus); PATB_BACSU (Bacillus subtilis); AAA85439 (Treponema denticola); AAO82584 (Enterococcus faecalis); CAD55570 (Corynebacterium glutamicum); NP_810311 (Bacteroides thetaiotaomicron);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence PATB_BACSU
Domain interval 27-382
Catalytic site 234 K
 
References
 Yano T, Fukamachi H, Yamamoto M, Igarashi T. (2009) Characterization of L-cysteine desulfhydrase from Prevotella intermedia Oral Microbiol Immunol 24 485-92.

 Martínez-Cuesta MC, Peláez C, Eagles J, Gasson MJ, Requena T, Hanniffy SB. (2006) YtjE from Lactococcus lactis IL1403 Is a C-S lyase with alpha, gamma-elimination activity toward methionine. Appl Environ Microbiol 72 4878-84.

 Auger, S.; Gomez, M.P.; Danchin, A.; Martin-Verstraete, I. (2005) The PatB protein of Bacillus subtilis is a C-S-lyase Biochimie 87 231-238.

 Wada, M., Awano, N., Haisa, K., Takagi, H., Nakamori, S. (2002) Purification, characterization and identification of cysteine desulfhydrase of Corynebacterium glutamicum, and its relationship to cysteine production FEMS Microbiol Lett 217 103-107.

 Krupka HI, Huber R, Holt SC, Clausen T. (2000) Crystal structure of cystalysin from Treponema denticola: a pyridoxal 5'-phosphate-dependent protein acting as a haemolytic enzyme EMBO J 19 3168-78.

 Chu, L.; Ebersole, J. L.; Kurzban, G. P.; Holt, S. C. (1999) Cystalysin, a 46-kDa L-cysteine desulfhydrase from Treponema denticola: biochemical and biophysical characterization Clin Infect Dis 28 442-50.

 Rossol, I.; Puhler, A. (1992) The Corynebacterium glutamicum aecD gene encodes a C-S lyase with alpha, beta-elimination activity that degrades aminoethylcysteine J Bacteriol 174 2968-77.

Articles on cysteine.desulfhydrase.a
last changed 2010/06/18 17:56

B6db families