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B6db families: lipk

lipk
Activity lipk
Description L-threonine--uridine -5-aldehyde transaldolase (2.2.1.-)
Notes Small family of bacterial enzymes, related to glycine hydroxymethyltransferase (family 2.1.2.1)
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences 9
Sequences in seed alignment
BacteriaBAO20189 (Sphaerisporangium sp. SANK 60911); BAM98975 (Streptosporangium amethystogenes); ADZ45329 (Streptomyces sp. NRRL 30471); BAJ05887 (Streptomyces sp. SANK 60405); ADC96660 (Streptomyces sp. SN-1061M); WP_020124815 (Streptomyces canus); BAJ19052 (Streptomyces sp. SANK 62799); 2585692396 (Micromonospora echinospora DSM 1040); EWC64470 (Actinokineospora);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence BAJ05887
Domain interval 11-387
Catalytic site 235 K
 
References
 Cui Z, Liu X, Overbay J, Cai W, Wang X, Lemke A, Wiegmann D, Niro G, Thorson JS, Ducho C, Van Lanen SG (2018) Enzymatic Synthesis of the Ribosylated Glycyl-Uridine Disaccharide Core of Peptidyl Nucleoside Antibiotics J Org Chem 83 7239-7249.

 Huang Y, Liu X, Cui Z, Wiegmann D, Niro G, Ducho C, Song Y, Yang Z, Van Lanen SG. (2018) Pyridoxal-5'-phosphate as an oxygenase cofactor: Discovery of a carboxamide-forming, alfa-amino acid monooxygenase-decarboxylase. Proc Natl Acad Sci U S A. 115 974-979.

 Funabashi M, Baba S, Takatsu T, Kizuka M, Ohata Y, Tanaka M, Nonaka K, Spork AP, Ducho C, Chen WC, Van Lanen SG (2013) Structure-based gene targeting discovery of sphaerimicin, a bacterial translocase I inhibitor Angew Chem Int Ed Engl 52 11607-11.

 Barnard-Britson, S,; Chi, X.; Nonaka, K.; Spork, A.P.; Tibrewal, N.; Goswami, A.; Pahari, P.; Ducho, C.; Rohr, J.; Van Lanen, S.G. (2012) Amalgamation of Nucleosides and Amino Acids in Antibiotic Biosynthesis: Discovery of an L-Threonine:Uridine-5'-Aldehyde Transaldolase J Am Chem Soc 134 18514-7.

Articles on lipk
last changed 2017/06/23 17:57

B6db families