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mcce |
Activity |
mcce |
Description |
Microcin biosynthesis intermediate decarboxylase (4.1.1.-) |
Notes |
The only functionally validated protein with this activity is from E. coli. Its sequence is distantly related to 4.1.1.20, diaminopimelate decarboxylase.
Often but not always these sequences bear at the c-terminus an extra n-acetyltransferase domain. This domain itself seems dispensable for the aminopropylation reaction involving MccE, and has been removed from the sequences in this family (including the reference sequence). |
PLP Fold Type |
III |
PLP-dependent Domain |
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Number of sequences |
10 |
Sequences in seed alignment |
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Reference sequence |
ABW37145 |
Domain interval |
38-277 |
Catalytic site |
62 K |
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References |
Bantysh O, Serebryakova M, Makarova KS, Dubiley S, Datsenko KA, Severinov K
(2014) Enzymatic synthesis of bioinformatically predicted microcin C-like compounds encoded by diverse bacteria MBio 5 e01059-14. Kulikovsky A, Serebryakova M, Bantysh O, Metlitskaya A, Borukhov S, Severinov K, Dubiley S.
(2014) The molecular mechanism of aminopropylation of peptide-nucleotide antibiotic microcin C
J Am Chem Soc 136 11168-75. Articles on mcce |
last changed |
2018/04/24 11:25 |
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