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B6db families: mcce

Activity mcce
Description Microcin biosynthesis intermediate decarboxylase (4.1.1.-)
Notes The only functionally validated protein with this activity is from E. coli. Its sequence is distantly related to, diaminopimelate decarboxylase.
Often but not always these sequences bear at the c-terminus an extra n-acetyltransferase domain. This domain itself seems dispensable for the aminopropylation reaction involving MccE, and has been removed from the sequences in this family (including the reference sequence).
PLP Fold Type III
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type III

Reference sequence ABW37145
Domain interval 38-277
Catalytic site 62 K
 Bantysh O, Serebryakova M, Makarova KS, Dubiley S, Datsenko KA, Severinov K (2014) Enzymatic synthesis of bioinformatically predicted microcin C-like compounds encoded by diverse bacteria MBio 5 e01059-14.

 Kulikovsky A, Serebryakova M, Bantysh O, Metlitskaya A, Borukhov S, Severinov K, Dubiley S. (2014) The molecular mechanism of aminopropylation of peptide-nucleotide antibiotic microcin C J Am Chem Soc 136 11168-75.

Articles on mcce
last changed 2018/04/24 11:25

B6db families