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B6db families: mocr

Activity mocr
Description mocR-like proteins
Notes The family is composed of bacterial proteins that act primarily as transcriptional regulators, but retain an intact aminotransferase domain.
Indeed, all MocR-like regulators exhibit a PLP attachment site with a conserved lysine residue.

In C. glutamicum, genetic data suggest that a protein of the MocR family functions as an aminotransferase in valine biosynthesis. The gene encoding this protein is located upstream of a potential operon of a newly described pyridoxine biosynthetic pathway and when disrupted, gives rise to a pyridoxine auxotrophy.

PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
Sequences in seed alignment
BacteriaPDXR_CORGL (Corynebacterium glutamicum); AAR33353 (Geobacter sulfurreducens); AAK25078 (Caulobacter crescentus); PTSJ_SALTY (Salmonella typhimurium); ZP_00162162 (Anabaena variabilis); CAE42855 (Bordetella pertussis); YP_011299 (Desulfovibrio vulgaris); CAB12197 (Bacillus subtilis); ZP_00222078 (Burkholderia cepacia); YCXD_BACSU (Bacillus subtilis); AAG02195 (Streptomyces venezuelae); YRDX_RHOSH (Rhodobacter sphaeroides); ZP_00311934 (Clostridium thermocellum); MOCR_RHIME (Sinorhizobium meliloti); CAE37655 (Bordetella parapertussis); ZP_00053760 (Magnetospirillum magnetotacticum); AAF01064 (Streptomyces venezuelae); CAB12787 (Bacillus subtilis); NP_824604 (Streptomyces avermitilis);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence YCXD_BACSU
Domain interval 78-440
Catalytic site 286 K
 McHardy AC, Tauch A, Rückert C, Pühler A, Kalinowski J. (2003) Genome-based analysis of biosynthetic aminotransferase genes of Corynebacterium glutamicum J Biotechnol 104 229-40.

Articles on mocr
last changed 2008/06/17 11:28

B6db families