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mocr |
Activity |
mocr |
Description |
mocR-like proteins |
Notes |
The family is composed of bacterial proteins that act primarily as transcriptional regulators, but retain an intact aminotransferase domain.
Indeed, all MocR-like regulators exhibit a PLP attachment site with a conserved lysine residue.
In C. glutamicum, genetic data suggest that a protein of the MocR family functions as an aminotransferase in valine biosynthesis. The gene encoding this protein is located upstream of a potential operon of a newly described pyridoxine biosynthetic pathway and when disrupted, gives rise to a pyridoxine auxotrophy. |
PDB |
5X03; |
PLP Fold Type |
I |
PLP-dependent Domain |
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Number of sequences |
22 |
Sequences in seed alignment |
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Reference sequence |
YCXD_BACSU |
Domain interval |
78-440 |
Catalytic site |
286 K |
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References |
Schulz A, Stöveken N, Binzen IM, Hoffmann T, Heider J, Bremer E (2017) Feeding on compatible solutes: A substrate-induced pathway for uptake and catabolism of ectoines and its genetic control by EnuR Environ Microbiol 19 926-946. Tramonti A, Milano T, Nardella C, di Salvo ML, Pascarella S, Contestabile R (2017) Salmonella typhimurium PtsJ is a novel MocR-like transcriptional repressor involved in regulating the vitamin B6 salvage pathway FEBS J 284 466-484. Yu Q, Cai H, Zhang Y, He Y, Chen L, Merritt J, Zhang S, Dong Z (2017) Negative Regulation of Ectoine Uptake and Catabolism in Sinorhizobium meliloti: Characterization of the EhuR Gene J Bacteriol 199 e00119-16. Okuda K, Kato S, Ito T, Shiraki S, Kawase Y, Goto M, Kawashima S, Hemmi H, Fukada H, Yoshimura T. (2015) Role of the aminotransferase domain in Bacillus subtilis GabR, a pyridoxal 5'-phosphate-dependent transcriptional regulator Mol Microbiol 95 245-57. Takenaka T, Ito T, Miyahara I, Hemmi H, Yoshimura T (2015) A new member of MocR/GabR-type PLP-binding regulator of D-alanyl-D-alanine ligase in Brevibacillus brevis FEBS J 282 4201-17. Tramonti A, Fiascarelli A, Milano T, di Salvo ML, Nogués I, Pascarella S, Contestabile R (2015) Molecular mechanism of PdxR – a transcriptional activator involved in the regulation of vitamin B6 biosynthesis in the probiotic bacterium Bacillus clausii FEBS J 282 2966-84. Belitsky, B.R. (2004) Bacillus subtilis GabR, a Protein with DNA-binding and Aminotransferase Domains, is a PLP-dependent Transcriptional Regulator J Mol Biol 340 655-64. McHardy AC, Tauch A, Rückert C, Pühler A, Kalinowski J. (2003) Genome-based analysis of biosynthetic aminotransferase genes of Corynebacterium glutamicum J Biotechnol 104 229-40. Articles on mocr |
last changed |
2017/10/26 14:42 |
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