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B6db families: mppp

mppp
Activity mppp
Description Arginine 4-hydroxylase/deaminase (1.13.12.-)
Notes A distinct (but quite heterogeneous) family of bacterial enzymes, structurally and functionally very similar to the family Ind4.

Other that that, the family is distantly related to capreomycidin synthase (4.2.1.145).

PDB 5DJ1;6C3B;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Reference sequence KDR62041
Domain interval 56-369
Catalytic site 221 K
 
References
 Han L, Vuksanovic N, Oehm SA, Fenske TG, Schwabacher AW, Silvaggi N. (2018) Streptomyces wadayamensis MppP is a PLP-dependent oxidase, not an oxygenase Biochemistry 57 3252-3264.

 Hedges JB, Kuatsjah E, Du YL, Eltis LD, Ryan KS. (2018) Snapshots of the catalytic cycle of an O2, pyridoxal phosphate-dependent hydroxylase. ACS Chem Biol 13 965-974.

 Han L, Schwabacher AW, Moran GR, Silvaggi NR (2015) Streptomyces wadayamensis MppP Is a Pyridoxal 5'-Phosphate-Dependent L-Arginine α-Deaminase, γ-Hydroxylase in the Enduracididine Biosynthetic Pathway Biochemistry 54 7029-40.

Articles on mppp
last changed 2018/03/01 12:54

B6db families