|
|
mppp |
Activity |
mppp |
Description |
Arginine 4-hydroxylase/deaminase (1.13.12.-) |
Notes |
A distinct (but quite heterogeneous) family of bacterial enzymes, structurally and functionally very similar to the family Ind4. Other that that, the family is distantly related to capreomycidin synthase (4.2.1.145). |
PDB |
5DJ1;6C3B; |
PLP Fold Type |
I |
PLP-dependent Domain |
|
Number of sequences |
15 |
Sequences in seed alignment |
|
Reference sequence |
KDR62041 |
Domain interval |
56-369 |
Catalytic site |
221 K |
| |
References |
Han L, Vuksanovic N, Oehm SA, Fenske TG, Schwabacher AW, Silvaggi N. (2018) Streptomyces wadayamensis MppP is a PLP-dependent oxidase, not an oxygenase Biochemistry 57 3252-3264. Hedges JB, Kuatsjah E, Du YL, Eltis LD, Ryan KS. (2018) Snapshots of the catalytic cycle of an O2, pyridoxal phosphate-dependent hydroxylase. ACS Chem Biol 13 965-974. Han L, Schwabacher AW, Moran GR, Silvaggi NR (2015) Streptomyces wadayamensis MppP Is a Pyridoxal 5'-Phosphate-Dependent L-Arginine α-Deaminase, γ-Hydroxylase in the Enduracididine Biosynthetic Pathway Biochemistry 54 7029-40. Articles on mppp |
last changed |
2018/03/01 12:54 |
|