B6db families : odcp

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odcp

Activity

Description

Ornithine decarboxylase paralogue

Notes

These metazoan proteins are fold-type III, similar to lysine and ornithine decarboxylases (families 4.1.1.18 and 4.1.17_1).

However, experimental data show that THESE PROTEINS ARE NOT ENZYMES. Rather, they act as ANTIZYME INHIBITORS, and are apparently involved in the regulation of polyamine biosynthesis

PLP Fold Type

III

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type III

Number of sequences

Sequences in seed alignment

Metazoa

AAQ62560 (Homo sapiens); XP_535320 (Canis familiaris); NP_766463 (Mus musculus); NP_001015993 (Xenopus tropicalis);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

AAQ62560

Domain interval

45-283

Catalytic site

n/a

References

Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC. (2008) Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase Biochem J 409 187-92.

López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R. (2006) Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity J Biol Chem 281 30896-906.

Koguchi K, Kobayashi S, Hayashi T, Matsufuji S, Murakami Y, Hayashi S. (1997) Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor Biochim Biophys Acta 1353 209-16.

Articles on odcp

last changed

2009/01/08 13:23