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B6db families: odcp

odcp
Activity odcp
Description Ornithine decarboxylase paralogue
Notes These metazoan proteins are fold-type III, similar to lysine and ornithine decarboxylases (families 4.1.1.18 and 4.1.17_1).

However, experimental data show that THESE PROTEINS ARE NOT ENZYMES. Rather, they act as ANTIZYME INHIBITORS, and are apparently involved in the regulation of polyamine biosynthesis

PLP Fold Type III
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type III

Number of sequences
4
Sequences in seed alignment
MetazoaAAQ62560 (Homo sapiens); XP_535320 (Canis familiaris); NP_766463 (Mus musculus); NP_001015993 (Xenopus tropicalis);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence AAQ62560
Domain interval 45-283
Catalytic site n/a
 
References
 Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC. (2008) Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase Biochem J 409 187-92.

 López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R. (2006) Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity J Biol Chem 281 30896-906.

 Koguchi K, Kobayashi S, Hayashi T, Matsufuji S, Murakami Y, Hayashi S. (1997) Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor Biochim Biophys Acta 1353 209-16.

Articles on odcp
last changed 2009/01/08 13:23

B6db families