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B6db families: pqra

pqra
Activity pqra
Description 5-amino-4-keto 6-phenylhexanoate synthase (2.5.1.-)
Notes A small family of apparently specialized bacterial enzymes,distantly similar to families of enzymes catalyzing similar reactions, such as ktmb and 2.3.1.47 (7-keto-8-aminopelargonate synthetase).

The only validated sequence (from Streptomyces sp. IB2014/016-6) is not yet publicly available, so the family has been based on the homologous protein from S. odonnellii.

PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Reference sequence WP_046500491
Domain interval 51-410
Catalytic site 265 K
 
References
 Rebets Y, Nadmid S, Paulus C, Dalem C, Hermann J, Hübner H, Rückert C, Kiemer A, Gmeiner P, Kalinowski J, Müller R, Luzhetskyy A (2019) Perquinolines A-C: Unprecedented Bacterial Tetrahydroisoquinolines Involving an Intriguing Biosynthesis Angew Chem Int Ed Engl 58 12930-12934.

Articles on pqra
last changed 2019/08/08 10:49

B6db families