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B6db families:

uncharacterized family prosc
Activity unclassified
Description unclassified activities
Notes Synonims: COG0325; YggS (E. coli), FkuA (Vibrio alginoliticus), ylmE (B. subtilis).

The prototype of this family, yeast hypothetical protein YBL036c, is homologous to a P. aeruginosa protein whose gene is co-transcribed with a known proline biosynthetic gene. The structure of the yeast protein shows a covalently bound PLP.

PDB 1B54;
PLP Fold Type III
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type III

Reference sequence NP_009517
Domain interval 20-249
Catalytic site 49 K
 Darin N, Reid E, Prunetti L, Samuelsson L, Husain RA, Wilson M, El Yacoubi B, Footitt E, Chong WK, Wilson LC, Prunty H, Pope S, Heales S, Lascelles K, Champion M, Wassmer E, Veggiotti P, de Crécy-Lagard V, Mills PB, Clayton PT (2016) Mutations in PROSC Disrupt Cellular Pyridoxal Phosphate Homeostasis and Cause Vitamin-B6-Dependent Epilepsy Am J Hum Genet 99 1325-1337.

 Prunetti L, El Yacoubi B, Schiavon CR, Kirkpatrick E, Huang L, Bailly M, ElBadawi-Sidhu M, Harrison K, Gregory JF, Fiehn O, Hanson AD, de Crécy-Lagard V (2016) Evidence That COG0325 Proteins are involved in PLP Homeostasis Microbiology 195 694-706.

 Ito T1, Iimori J, Takayama S, Moriyama A, Yamauchi A, Hemmi H, Yoshimura T. (2013) Conserved pyridoxal protein that regulates Ile and Val metabolism J Bacteriol. 195 5439-49.

 Eswaramoorthy, S.; Gerchman, S,; Graziano, V.; Kycia, H.; Studier, F.W.; Swaminathan, S. (2003) Structure of a yeast hypothetical protein selected by a structural genomics approach. Acta Crystallogr D Biol Crystallogr. 59 127-135.

 Ikegawa S.; Isomura M.; Koshizuka Y.; Nakamura Y. (1999) Cloning and characterization of human and mouse PROSC (proline synthetase co-transcribed) genes J Hum Genet. 44 337-342.

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last changed 2019/05/28 09:58

B6db families