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B6db families:

uncharacterized family prosc
Activity unclassified
Description unclassified activities
Notes Synonims: COG0325; YggS (E. coli), FkuA (Vibrio alginoliticus), ylmE (B. subtilis).

The prototype of this family, yeast hypothetical protein YBL036c, is homologous to a P. aeruginosa protein whose gene is co-transcribed with a known proline biosynthetic gene. The structure of the yeast protein shows a covalently bound PLP.

PDB 1B54;
PLP Fold Type III
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type III

Number of sequences 16
Sequences in seed alignment
BacteriaWP_011244343 (Synechococcus elongatus); YP_670830 (Escherichia coli 536); AAY95028 (Pseudomonas fluorescens Pf-5); AGL50663 (Thermotoga maritima MSB8); NP_899848 (Chromobacterium violaceum ATCC 12472); BAA09062 (Vibrio alginolyticus); YLME_BACSU (Bacillus subtilis);
FungiCAH02469 (Kluyveromyces lactis); NP_009517 (Saccharomyces cerevisiae); RGP77308 (Fusarium longipes); XP_001560727 (Botrytis cinerea B05.10); CAB90136 (Schizosaccharomyces pombe);
MetazoaAAA79348 (Caenorhabditis elegans); EAW63364 (Homo sapiens);
ViridiplantaeNP_849649 (Arabidopsis thaliana); CAL50357 (Ostreococcus tauri);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence NP_009517
Domain interval 20-249
Catalytic site 49 K
 Darin N, Reid E, Prunetti L, Samuelsson L, Husain RA, Wilson M, El Yacoubi B, Footitt E, Chong WK, Wilson LC, Prunty H, Pope S, Heales S, Lascelles K, Champion M, Wassmer E, Veggiotti P, de Crécy-Lagard V, Mills PB, Clayton PT (2016) Mutations in PROSC Disrupt Cellular Pyridoxal Phosphate Homeostasis and Cause Vitamin-B6-Dependent Epilepsy Am J Hum Genet 99 1325-1337.

 Prunetti L, El Yacoubi B, Schiavon CR, Kirkpatrick E, Huang L, Bailly M, ElBadawi-Sidhu M, Harrison K, Gregory JF, Fiehn O, Hanson AD, de Crécy-Lagard V (2016) Evidence That COG0325 Proteins are involved in PLP Homeostasis Microbiology 195 694-706.

 Ito T1, Iimori J, Takayama S, Moriyama A, Yamauchi A, Hemmi H, Yoshimura T. (2013) Conserved pyridoxal protein that regulates Ile and Val metabolism J Bacteriol. 195 5439-49.

 Eswaramoorthy, S.; Gerchman, S,; Graziano, V.; Kycia, H.; Studier, F.W.; Swaminathan, S. (2003) Structure of a yeast hypothetical protein selected by a structural genomics approach. Acta Crystallogr D Biol Crystallogr. 59 127-135.

 Ikegawa S.; Isomura M.; Koshizuka Y.; Nakamura Y. (1999) Cloning and characterization of human and mouse PROSC (proline synthetase co-transcribed) genes J Hum Genet. 44 337-342.

Articles on
last changed 2019/05/28 09:58

B6db families