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uncharacterized family yhfs |
Activity |
unclassified |
Description |
unclassified activities |
Notes |
Very distinct family of bacterial proteins, built based on Yhfs from E. coli (whose structure is known). Sequences in this family are distantly related to methionine gamma-lyases (family 4.4.1.11) and other C-S lyases, but also to the mocr group of proteins.
Under anaerobiosis, yhfS gene expression is activated by the transcriptional activator FNR. A ΔyhfS mutant has aggravating genetic interactions with genes involved in DNA recombination (source: https://biocyc.org/gene?orgid=ECOLI&id=G7728)
The yhfs genes normally cluster together with genes of the yhfx family (see unclassified_family_yhfx). The connection is particularly evident in firmicutes such as Lactobacillus rhamnosum, Jeotgalibaca dankookensis, Carnobacterium sp AT7.
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PDB |
4J8L; |
PLP Fold Type |
I |
PLP-dependent Domain |
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Number of sequences |
15 |
Sequences in seed alignment |
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Reference sequence |
P45545 |
Domain interval |
39-236 |
Catalytic site |
196 K |
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References |
Articles on uncharacterized.family.yhfs |
last changed |
2018/02/09 10:49 |
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