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B6db families: uncharacterized.family.yhfx

uncharacterized family yhfx
Activity unclassified
Description unclassified activities
Notes YhfX from E. coli is a protein belonging to the Fold-type III group and distantly similar, in particular, to ornithine racemases (Family 5.1.1.12).
FTIII racemases usually contain a N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, but in this case the C-terminal domain is not recognized by pfam .
The YhfX structure (deposited in PDB, but not described in the literature) shows a covalently PLP-modified residue N6-(pyridoxal phosphate)lysine at the expected site (conserved Lys61).

NOTE: in many firmicutes (e.g., Lactobacillus rhamnosum, Jeotgalibaca dankookensis, Carnobacterium sp AT7) the yfhx gene is closely associated to a putative PLP-dependent C-S lyase (unclassified_family_yhfs).

PDB 4KDX;
PLP Fold Type III
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type III

Reference sequence NP_417840
Domain interval 33-264
Catalytic site 61 K
 
References Articles on uncharacterized.family.yhfx
last changed 2018/02/09 10:43

B6db families