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B6db Fold_types: 3

Fold type III

PLP-binding barrel. Circular permutation of the canonical fold: begins with an alpha helix and ends with a beta-strand.

Prototype sequence:
ALR_BACST - Alanine racemase

Prototype structure:
PDB 1sft;

Grishin Protein Sci. 1995

PLP-dependent families with this fold:

4.1.1.116 (11) 4.1.1.117 (11) 4.1.1.17_1 (45) 4.1.1.18_a (10) 4.1.1.18_d (2) 4.1.1.19_1 (29) 4.1.1.20 (43) 4.1.1.95 (4) 4.1.1.96 (16) 4.1.2.42 (17) 4.1.3.41 (18) 4.3.1.18_b (11) 4.3.1.27 (11) 5.1.1.12 (15) 5.1.1.1_a (49) 5.1.1.24 (3) 5.1.1.5_a (20) 5.1.1.5_b (6) 5.1.1.5_c (4) ctaf (1) d-aa deaminase (11) flvo (3) fslc (4) gm853 (10) mcce (10) odcp (15) smmdc (5) temporary_acse (3) uncharacterized_family_prosc (16) uncharacterized_family_yhfx (24) vino (9) xodc2 (5)

 Eswaramoorthy, S.; Gerchman, S,; Graziano, V.; Kycia, H.; Studier, F.W.; Swaminathan, S. (2003) Structure of a yeast hypothetical protein selected by a structural genomics approach. Acta Crystallogr D Biol Crystallogr. 59 127-135.

 Shaw, J.P.; Petsko, G.A.; Ringe, D. (1997) Determination of the structure of alanine racemase from Bacillus stearothermophilus at 1.9-A resolution. Biochemistry 36 1329-1342.


B6db Fold_types