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Fold type III PLP-binding barrel. Circular permutation of the canonical fold: begins with an alpha helix and ends with a beta-strand. Prototype sequence: ALR_BACST - Alanine racemase
Prototype structure: PDB 1sft;
Grishin Protein Sci. 1995 |
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PLP-dependent families with this fold:
Eswaramoorthy, S.; Gerchman, S,; Graziano, V.; Kycia, H.; Studier, F.W.; Swaminathan, S. (2003) Structure of a yeast hypothetical protein selected by a structural genomics approach. Acta Crystallogr D Biol Crystallogr. 59 127-135. Shaw, J.P.; Petsko, G.A.; Ringe, D. (1997) Determination of the structure of alanine racemase from Bacillus stearothermophilus at 1.9-A resolution. Biochemistry 36 1329-1342.
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