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B6db Fold_types: 3

Fold type III

PLP-binding barrel. Circular permutation of the canonical fold: begins with an alpha helix and ends with a beta-strand.

Prototype sequence:
ALR_BACST - Alanine racemase

Prototype structure:
PDB 1sft;

Grishin Protein Sci. 1995

PLP-dependent families with this fold:


 Ito T1, Iimori J, Takayama S, Moriyama A, Yamauchi A, Hemmi H, Yoshimura T. (2013) Conserved pyridoxal protein that regulates Ile and Val metabolism J Bacteriol. 195 5439-49.

 Eswaramoorthy, S.; Gerchman, S,; Graziano, V.; Kycia, H.; Studier, F.W.; Swaminathan, S. (2003) Structure of a yeast hypothetical protein selected by a structural genomics approach. Acta Crystallogr D Biol Crystallogr. 59 127-135.

 Shaw, J.P.; Petsko, G.A.; Ringe, D. (1997) Determination of the structure of alanine racemase from Bacillus stearothermophilus at 1.9-A resolution. Biochemistry 36 1329-1342.


B6db Fold_types