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B6db Fold_types: 6

Fold type VI

TIM- barrel, with the PLP imine linkage formed to the AdoCbl-binding Rossmann domain/subunit rather than to a lysine of the TIM barrel. PLP occupies a different position as compared to the alanine racemase (fold-type III) TIM-barrel.

Prototype sequence:
AAC79717 - D-lysine 5,6-aminomutase

Prototype structure:
PDB 1XRS;

PLP-dependent families with this fold:

5.4.3.4 (7) 5.4.3.5 (5)

 Berkovitch, F.; Behshad, E.; Tang, K.H.; Enns, E.A.; Frey, P.A.; Drennan, C.L. (2004) A locking mechanism preventing radical damage in the absence of substrate, as revealed by the x-ray structure of lysine 5,6-aminomutase Proc Natl Acad Sci U S A 101 15870-5.


B6db Fold_types