B6db activities : 2_3_1

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	2.3.1.263
Description	2-amino-4-oxopentanoate thiolase
Alternative names	AKPT; AKP thiolase; 2-amino-4-ketopentanoate thiolase
Catalyzed reaction	acetyl-CoA + D-alanine = CoA + (2R)-2-amino-4-oxopentanoate
Cofactor	Pyridoxal-phosphate.
Comments	A pyridoxal 5'-phosphate enzyme. The enzyme, characterized from the bacterium Clostridium sticklandii, is part of a degradation pathway of ornithine. It is specific for acetyl-CoA and D-alanine
Organisms	-Eubacteria
Family	2.3.1.263 (0)

Links	Enzyme (activities) 2.3.1.263 BRENDA (activities) 2.3.1.263 KEGG (pathways) 2.3.1.263 PLPMDB (PLP mutants) 2.3.1.263

References	Fonknechten N1, Perret A, Perchat N, Tricot S, Lechaplais C, Vallenet D, Vergne C, Zaparucha A, Le Paslier D, Weissenbach J, Salanoubat M (2009) A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine J Bacteriol 191 3162-7. Jeng IM, Somack R, Barker HA. (1974) Ornithine degradation in Clostridium sticklandii; pyridoxal phosphate and coenzyme A dependent thiolytic cleavage of 2-amino-4-ketopentanoate to alanine and acetyl coenzyme A. Biochemistry 13 2898-903. Articles on 2.3.1.263

last changed	2018/02/13 18:10

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