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2.6.1.101 |
| Description |
L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase |
| Alternative names |
L-glutamine:5-amino-2,3,4-trihydroxycyclohexanone aminotransferase |
| Catalyzed reaction |
L-glutamine + 3-amino-2,3-dideoxy-scyllo-inosose = 2-oxoglutaramate + 2-deoxystreptamine |
| Cofactor |
Pyridoxal-phosphate. |
| Comments |
Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Also catalyses EC 2.6.1.100, L-glutamine:2-deoxy-scyllo-inosose aminotransferase.
Enzymes with this activity have been included in family 2.6.1.101. |
| PDB |
2C7T; 2C81; |
| Organisms |
-Eubacteria |
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| Links |
Enzyme (activities) 2.6.1.101
BRENDA (activities) 2.6.1.101
KEGG (pathways) 2.6.1.101
PLPMDB (PLP mutants) 2.6.1.101
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| References |
Huang F, Haydock SF, Mironenko T, Spiteller D, Li Y, Spencer JB.
(2005) The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine
Org Biomol Chem 3 1410-8. Kudo F, Yamamoto Y, Yokoyama K, Eguchi T, Kakinuma K.
(2005) Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773
J Antibiot (Tokyo) 58 766-74. Tamegai, H.; Nango, E.; Kuwahara, M.; Yamamoto, H.; Ota, Y.; Kuriki, H.; Eguchi, T.; Kakinuma, K. (2002) Identification of L-glutamine: 2-deoxy-scyllo-inosose aminotransferase required for the biosynthesis of butirosin in Bacillus circulans J Antibiot (Tokyo) 55 707-714. |
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| last changed |
2017/11/03 18:18 |
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