B6db activities : 2_6_1

	Activities \| Families \| Sequences \| Fold types \| References \| Help


	2.6.1.110
Description	dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase
Alternative names	dTDP-4-dehydro-2,3,6-trideoxy-D-glucose--glutamate aminotransferase; dTDP-4-amino-2,3,4,6-tetradeoxy-β-D-threo-hexopyranose-oxoglutarate aminotransferase; spnR (gene name)
Catalyzed reaction	dTDP-4-dehydro-2,3,6-trideoxy-D-glucose + L-glutamate = dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose + 2-oxoglutarate
Cofactor	Pyridoxal phosphate.
Comments	The enzyme, isolated from the bacterium Saccharopolyspora spinosa, participates in the biosynthesis of forosamine.
	Forosamine is a highly deoxygenated sugar found in several natural products, such as the insecticide spinosyns. The enzyme from Saccharopolyspora spinosa also catalyzes the transamination of dTDP-4-keto-2,6-dideoxy-d-glucose.
Organisms	-Eubacteria
Family	2.6.1.110 (0)

Links	Enzyme (activities) 2.6.1.110 BRENDA (activities) 2.6.1.110 KEGG (pathways) 2.6.1.110 PLPMDB (PLP mutants) 2.6.1.110

References	Hong L, Zhao Z, Melançon CE 3rd, Zhang H, Liu HW (2008) In vitro characterization of the enzymes involved in TDP-D-forosamine biosynthesis in the spinosyn pathway of Saccharopolyspora spinosa J Am Chem Soc 130 4954-67. Zhao Z, Hong L, Liu HW. (2005) Characterization of protein encoded by spnR from the spinosyn gene cluster of Saccharopolyspora spinosa: mechanistic implications for forosamine biosynthesis J Am Chem Soc 127 7692-3. Articles on 2.6.1.110

last changed	2017/09/07 12:03

Family