B6db activities : 2_6_1

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	2.6.1.112
Description	(S)-ureidoglycine--glyoxylate transaminase
Alternative names	Ureidoglycine--glyoxylate aminotransferase ; pucG (gene name);
Catalyzed reaction	(S)-ureidoglycine + glyoxylate = N-carbamoyl-2-oxoglycine + glycine
Cofactor	Pyridoxal phosphate.
Comments	-!- Can also use several keto acids (e.g., 2-oxoglutarate) as amino-group acceptors.
	In certain bacteria, the catalyzed reaction is part of the urate degradation pathway. The product N-carbamoyl-2-oxoglycine is also called oxalurate.
PDB	3ISL; 3NNK;
Organisms	-Eubacteria
Family	2.6.1.112 (0)

Links	Enzyme (activities) 2.6.1.112 BRENDA (activities) 2.6.1.112 KEGG (pathways) 2.6.1.112 PLPMDB (PLP mutants) 2.6.1.112

References	French JB, Ealick SE. (2010) Biochemical and structural characterization of a ureidoglycine aminotransferase in the Klebsiella pneumoniae uric acid catabolic pathway. Biochemistry 49 5975-7. Ramazzina, I.; Costa, R.; Cendron, L.; Berni, R.; Peracchi, A.; Zanotti, G.; Percudani, R. (2010) An aminotransferase branch point connects purine catabolism to amino acid recycling Nat Chem Biol 6 801-806. Articles on 2.6.1.112

last changed	2018/10/17 14:39

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