B6db activities : 2_6_1

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	2.6.1.115
Description	5-hydroxydodecatetraenal 1-aminotransferase
Alternative names	cpkG (gene name)
Catalyzed reaction	(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine
Cofactor	Pyridoxal phosphate
Comments	The enzyme, characterized from the bacterium Streptomyces coelicolor A3(2), participates in the biosynthesis of coelimycin P1, where it catalyses the amination of (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal. L-glutamate can also serve as the amino group donor with lower efficiency.
	The product of the gene ArpN, in Streptomyces argillaceus, could catalyze a similar but distinct reaction in the biosynthesis of Argimycins P alkaloids.
Organisms	-Eubacteria
Family	2.6.1.115 (0)

Links	Enzyme (activities) 2.6.1.115 BRENDA (activities) 2.6.1.115 KEGG (pathways) 2.6.1.115 PLPMDB (PLP mutants) 2.6.1.115

References	Awodi UR, Ronan JL, Masschelein J, de Los Santos ELC, Challis GL (2017) Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis Chem Sci 8 411-415. Articles on 2.6.1.115

last changed	2019/03/25 14:06

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