B6db activities : 4_1_1

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	4.1.1.108
Description	4-hydroxyphenylacetaldehyde synthase
Alternative names	TYRDC-2 (gene name)
Catalyzed reaction	L-tyrosine + O(2) = 4-hydroxyphenylacetaldehyde + H(2)O(2) + NH(3) + CO(2).
Cofactor	Pyridoxal-phosphate.
Comments	A pyridoxal 5'-phosphate protein. The enzyme, isolated from the the plant Petroselinum crispum (parsley), catalyses the production of 4-hydroxyphenylacetaldehyde directly from L-tyrosine. Tyramine is not formed as an intermediate. The enzyme has a low activity with L-dopa (cf. EC 4.1.1.107, 3,4-dihydroxyphenylacetaldehyde synthase).
Organisms	-Plants

Links	Enzyme (activities) 4.1.1.108 BRENDA (activities) 4.1.1.108 KEGG (pathways) 4.1.1.108 PLPMDB (PLP mutants) 4.1.1.108

References	Torrens-Spence MP1, Liu P, Ding H, Harich K, Gillaspy G, Li J (2013) Biochemical evaluation of the decarboxylation and decarboxylation-deamination activities of plant aromatic amino acid decarboxylases J Biol Chem 288 2376-87. Torrens-Spence MP, Gillaspy G, Zhao B, Harich K, White RH, Li J (2012) Biochemical evaluation of a parsley tyrosine decarboxylase results in a novel 4-hydroxyphenylacetaldehyde synthase enzyme Biochem Biophys Res Commun 418 211-6. Articles on 4.1.1.108

last changed	2018/05/09 15:51