B6db activities : 4_1_1

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	4.1.1.116
Description	D-ornithine/D-lysine decarboxylase
Alternative names	STM2360 (gene name);
Catalyzed reaction	D-ornithine = putrescine + CO(2) D-lysine = cadaverine + CO(2).
Cofactor	Pyridoxal-phosphate.
Comments	Glossary: cadaverine = pentane-1,5-diamine putrescine = butane-1,4-diamine The enzyme, characterized from the bacterium Salmonella typhimurium LT2, is specific for D-ornithine and D-lysine. Requires pyridoxal 5'-phosphate.
	The enzyme from S. typhimurium reacts more efficiently with D-ornithine.
PDB	6N2H;
Organisms	-Eubacteria
Family	4.1.1.116 (0)

Links	Enzyme (activities) 4.1.1.116 BRENDA (activities) 4.1.1.116 KEGG (pathways) 4.1.1.116 PLPMDB (PLP mutants) 4.1.1.116

References	Phillips RS, Poteh P, Krajcovic D, Miller KA, Hoover TR (2019) Crystal Structure of d-Ornithine/d-Lysine Decarboxylase, a Stereoinverting Decarboxylase: Implications for Substrate Specificity and Stereospecificity of Fold III Decarboxylases Biochemistry 58 1038-1042. Phillips RS, Poteh P, Miller KA, Hoover TR (2017) STM2360 encodes a d-ornithine/d-lysine decarboxylase in Salmonella enterica serovar typhimurium Arch Biochem Biophys 634 83-87. Articles on 4.1.1.116

last changed	2019/06/21 13:13

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