B6db activities : 4_1_1

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4.1.1.64

Description

2,2-dialkylglycine decarboxylase (pyruvate)

Alternative names

alpha-dialkylamino acid transaminase;
L-alanine-alpha-ketobutyrate aminotransferase;
DGD.

Catalyzed reaction

2,2-dialkylglycine + pyruvate = dialkyl ketone + CO(2) + L-alanine.

Cofactor

Pyridoxal-phosphate.

Comments

-!- Acts on 2-amino-2-methylpropanoate (i.e. 2-methylalanine), 2-amino-2-methylbutanoate and 1-aminocyclopentanecarboxylate.

Mechanistically, dialkylglycine decarboxylase is a very peculiar PLP-dependent enzyme, which catalyzes both decarboxylation and transamination in its normal catalytic cycle.

Enzymes with this activity occur sporadically in bacteria and fungi, but their biological role is unclear.

Prosite

PROSITE; PDOC00519;

PDB

1D7S; 1D7V;

Organisms

-Eubacteria -Fungi

Family

4.1.1.64 (0)

Links

Enzyme (activities) 4.1.1.64
BRENDA (activities) 4.1.1.64
KEGG (pathways) 4.1.1.64
PLPMDB (PLP mutants) 4.1.1.64

References

B6db references :

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Articles on 4.1.1.64

last changed

2019/06/21 13:11