B6db activities : 4_1_1

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	4.1.1.95
Description	L-glutamyl-[BtrI acyl-carrier protein] decarboxylase
Alternative names	L-glutamyl-[BtrI acyl-carrier protein] carboxy-lyase; btrK.
Catalyzed reaction	L-glutamyl-[BtrI acyl-carrier protein] = 4-amino butanoyl-[BtrI acyl-carrier protein] + CO2
Cofactor	Pyridoxal-phosphate.
Comments	Binds pyridoxal 5'-phosphate. Catalyses a step in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. Has very low activity with substrates not bound to an acyl-carrier protein.
Organisms	-Eubacteria
Family	4.1.1.95 (0)

Links	Enzyme (activities) 4.1.1.95 BRENDA (activities) 4.1.1.95 KEGG (pathways) 4.1.1.95 PLPMDB (PLP mutants) 4.1.1.95

References	Li, Y., Llewellyn, N.M., Giri, R., Huang, F. and Spencer, J.B. (2005) Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway. Chem. Biol. 12 665-75. Articles on 4.1.1.95

last changed	2019/06/21 13:12

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