B6db activities : 4_3_1

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4.3.1.16

Description

Threo-3-hydroxyaspartate ammonia-lyase

Alternative names

L-Threo-3-hydroxyaspartate dehydratase;
L-threo-3-hydroxyaspartate dehydratase.

Catalyzed reaction

Threo-3-hydroxy-L-aspartate = oxaloacetate + NH(3)

Cofactor

Pyridoxal-phosphate

Comments

-The enzyme from the bacterium Pseudomonas sp. T62 is highly specific, and does not accept any other stereoisomer of 3-hydroxyaspartate. -Different from EC 4.3.1.20 and EC 4.3.1.27.
-Requires a divalent cation such as Mn(2+), Mg(2+), or Ca(2+).

The enzyme from the bacterium Pseudomonas sp. T62 is highly specific, and does not accept any other stereoisomer of 3-hydroxyaspartate. In contrast, the homologous enzyme from Pseudomonas sp. N99 also efficiently degrades its enantiomer, D-erythro-3-hydroxyaspartate.

PDB

1V71;

Organisms

-Eubacteria -Fungi

Family

4.3.1.16 (0)

Links

Enzyme (activities) 4.3.1.16
BRENDA (activities) 4.3.1.16
KEGG (pathways) 4.3.1.16
PLPMDB (PLP mutants) 4.3.1.16

References

B6db references :

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Articles on 4.3.1.16

last changed

2019/06/20 13:41