B6db activities : 5_1_1

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	5.1.1.17
Description	Isopenicillin N epimerase
Alternative names	Penicillin-N 5-amino-5-carboxypentanoyl-epimerase.
Catalyzed reaction	Isopenicillin N = penicillin N
Cofactor	Pyridoxal-phosphate.
Comments	Epimerization at C-5 of the 5-amino-5-carboxypentanoyl group to form penicillin N is required to make a substrate for EC 1.14.20.1, to produce cephalosporins. Forms part of the penicillin biosynthesis pathway.
	While bacterial enzymes are PLP dependent, the formation of penicillin N in the fungus Acremonium chrysogenum requires a two-component protein system that comprises an isopenicillinyl-CoA ligase and an isopenicillinyl-CoA epimerase.
Organisms	-Eubacteria
Family	5.1.1.17 (0)

Links	Enzyme (activities) 5.1.1.17 BRENDA (activities) 5.1.1.17 KEGG (pathways) 5.1.1.17 PLPMDB (PLP mutants) 5.1.1.17

References	Kimura, H.; Izawa, M.; Sumino, Y. (1996) Molecular analysis of the gene cluster involved in cephalosporin biosynthesis from Lysobacter lactamgenus YK90 Appl Microbiol Biotechnol 44 589-96. Coque, J. J.; Martin, J. F.; Liras, P. (1993) Characterization and expression in Streptomyces lividans of cefD and cefE genes from Nocardia lactamdurans: the organization of the cephamycin gene cluster differs from that in Streptomyces clavuligerus Mol Gen Genet 236 453-8. Articles on 5.1.1.17

last changed	2010/02/02 10:19

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