B6db activities : abmd

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	abmd
Description	5'-glycyl-4'-thio uridine epimerase (5.1.1.-)
Alternative names	AbmD (gene name);
Catalyzed reaction	(5'S, 6'S)5'-glycyl-4'-thio uridine = (5'R, 6'S)5'-glycyl-4'-thio uridine
Cofactor	Pyridoxal-phosphate.
Comments	Involved in the biosynthesis of albomycin antibiotics. The substrate of the reaction is apparently generated by another PLP-dependent enzyme, L-threonine: uridine-4'-thio-5’-aldehyde transaldolase (family abmh).
Organisms	-Eubacteria
Family	abmd (0)

Links	Enzyme (activities) abmd BRENDA (activities) abmd KEGG (pathways) abmd PLPMDB (PLP mutants) abmd

References	Ushimaru R, Liu HW. (2019) Biosynthetic Origin of the Atypical Stereochemistry in the Thioheptose Core of Albomycin Nucleoside Antibiotics J Am Chem Soc 141 2211-2214. Articles on abmd

last changed	2019/06/20 18:13

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