B6db activities : acmh

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	acmh
Description	3-hydroxy-4-methyl-D-kynurenine hydrolase (3.7.1.-)
Catalyzed reaction	3-hydroxy-4-methyl-D-kynurenine + H(2)O = 3-hydroxy-4-methylanthranilate + L-alanine + H+
Cofactor	Pyridoxal phosphate
Comments	AcmH is involved in generating 3-hydroxy-4-methylanthranilate, a precursor for the biosynthesis of several secondary metabolites, including actinomycins.
Organisms	-Eubacteria
Family	acmh (0)

Links	Enzyme (activities) acmh BRENDA (activities) acmh KEGG (pathways) acmh PLPMDB (PLP mutants) acmh

References	Crnovcić I, Süssmuth R, Keller U. (2010) Aromatic C-methyltransferases with antipodal stereoselectivity for structurally diverse phenolic amino acids catalyze the methylation step in the biosynthesis of the actinomycin chromophore. Biochemistry. 49 9698-705. Articles on acmh

last changed	2018/04/19 12:18

Family