B6db activities : dhph-n

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dhph-n

Description

1-amino-2-(phosphohydroxy)ethyl-phosphonate phospho-lyase (4.2.3.-)

Alternative names

DhpH N-terminal domain;

Catalyzed reaction

[1-amino-2-(phosphohydroxy)ethyl]-phosphonate + H(2)O = = [1-oxo-ethyl]-phosphonate + + NH(3) + phosphate.

Cofactor

Pyridoxal-phosphate

Involved in biosynthesis of the broad-spectrum antibiotic dehydrophos.

The reaction is catalyzed by the N-terminal domain of the DhpH gene product. The [1-oxo-ethyl]-phosphonate, generated by this reaction is used as a substrate by DhpD, a second PLP-dependent enzyme in the dehydrophos pathway.
In turn, the DhpD product (1-amino-phosphonoethane) is condensed with a Leu molecule by the C-terminal domain of DhpH.

Organisms

-Eubacteria

Family

dhph-n (0)

Links

Enzyme (activities) dhph-n
BRENDA (activities) dhph-n
KEGG (pathways) dhph-n
PLPMDB (PLP mutants) dhph-n

References

B6db references :

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Articles on dhph-n

last changed

2019/06/20 13:07