B6db activities : dhph-n

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	dhph-n
Description	1-amino-2-(phosphohydroxy)ethyl-phosphonate phospho-lyase (4.2.3.-)
Alternative names	DhpH N-terminal domain;
Catalyzed reaction	[1-amino-2-(phosphohydroxy)ethyl]-phosphonate + H(2)O = = [1-oxo-ethyl]-phosphonate + + NH(3) + phosphate.
Cofactor	Pyridoxal-phosphate
	Involved in biosynthesis of the broad-spectrum antibiotic dehydrophos. The reaction is catalyzed by the N-terminal domain of the DhpH gene product. The [1-oxo-ethyl]-phosphonate, generated by this reaction is used as a substrate by DhpD, a second PLP-dependent enzyme in the dehydrophos pathway. In turn, the DhpD product (1-amino-phosphonoethane) is condensed with a Leu molecule by the C-terminal domain of DhpH.
Organisms	-Eubacteria
Family	dhph-n (0)

Links	Enzyme (activities) dhph-n BRENDA (activities) dhph-n KEGG (pathways) dhph-n PLPMDB (PLP mutants) dhph-n

References	Bougioukou DJ, Mukherjee S, van der Donk WA (2013) Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway Proc Natl Acad Sci U S A 110 10952-7. Articles on dhph-n

last changed	2019/06/20 13:07

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