B6db activities : gabt1

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	gabt1
Description	D-fructose-6-phosphate-L-glutamate transaminase (2.6.1.-)
Catalyzed reaction	keto-D-fructose 6-phosphate + L-glutamate = 2-amino-2-deoxy-mannitol-6-phosphate + 2-oxoglutarate.
Cofactor	Pyridoxal phosphate
Comments	The enzyme gabt1 catalyzes the first step in the biosynthesis of the azasugar mannojirimycin. This compound is an intermediate in the biosynthesis of the nojirimycins, which are glycosidase inhibitors.
Organisms	-Eubacteria
Family	gabt1 (0)

Links	Enzyme (activities) gabt1 BRENDA (activities) gabt1 KEGG (pathways) gabt1 PLPMDB (PLP mutants) gabt1

References	Arciola JM, Horenstein NA. (2018) Characterization of the PLP-dependent transaminase initiating azasugar biosynthesis Biochem J 475 2241-2256. Clark LF, Johnson JV, Horenstein NA (2011) Identification of a gene cluster that initiates azasugar biosynthesis in Bacillus amyloliquefaciens. Chembiochem 12 2147-50. Articles on gabt1

last changed	2019/06/20 18:14

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