B6db activities : glii

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	glii
Description	Twin carbon-sulfur lyase (4.4.1.-)
Alternative names	GliI (gene name); carbon-sulfate lyase;
Catalyzed reaction	A bis(cysteine) S-conjugate + H(2)O = reduced (dithiol) gliotoxin + 2 NH(3) + 2 pyruvate
Cofactor	Pyridoxal-phosphate
	Involved in the fungal production of gliotoxin. The mechanism of the enzyme is believed to involve two essentially simultaneous beta-elimination reactions occurring at the two cysteine moyeties of the substrate.
Organisms	-Fungi
Family	glii (0)

Links	Enzyme (activities) glii BRENDA (activities) glii KEGG (pathways) glii PLPMDB (PLP mutants) glii

References	Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Roth M, Brakhage AA, Hertweck C. (2012) Epidithiol formation by an unprecedented twin carbon-sulfur lyase in the gliotoxin pathway. Angew Chem Int Ed Engl 51 10064-8. Articles on glii

last changed	2018/04/16 17:11

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