B6db activities : marg

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	marg
Description	beta-methyltriptophan aminotransferase (2.6.1.-)
Catalyzed reaction	beta-methyl-L-triptophan + + 2-oxoglutarate = beta-methyl-beta-indole-pyruvate + L-glutamate
Cofactor	Pyridoxal-phosphate
Comments	The physiological reaction occurs in the opposite direction. Can use both stereoisomers of β-methyl-indolepyruvate, producing either (2S,3R)-β-methyltryptophan or (2S,3S)-β-methyltryptophan. It can also act as a tryptophan aminotransferase (EC 2.1.6.27).
	beta-methyltriptophan is a biosynthetic precursor of bioactive natural products such as maremycin A and B.
Organisms	-Eubacteria
Family	marg (0)

Links	Enzyme (activities) marg BRENDA (activities) marg KEGG (pathways) marg PLPMDB (PLP mutants) marg

References	Zou Y1, Fang Q, Yin H, Liang Z, Kong D, Bai L, Deng Z, Lin S. (2013) Stereospecific biosynthesis of β-methyltryptophan from (L)-tryptophan features a stereochemical switch Angew Chem Int Ed Engl 52 12951-5. Articles on marg

last changed	2017/09/08 08:52

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