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mur24 |
| Description |
Disaccharide alkyl acceptor aminobutyryltransferase (4.1.1.-) |
| Alternative names |
Aminobutyryl-transferase (ambiguous);
ABTase;
Mur24 (gene name). |
| Catalyzed reaction |
S-adenosyl-L-methionine + disaccharide alkyl acceptor = Aminobutyroylated disaccharide + methylthioadenosine. |
| Cofactor |
Pyridoxal-phosphate. |
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Catalyzes a gamma-substitution.
The validated bacterial enzyme is from a Streptomyces species and is involved in the biosynthesis of the dinucleoside core of muraymycins. Muraymycins are part of a broader group of antibiotics (including for example caprazamycin B and sphaerimicin A), which possess the same kind dinucleoside of core and which inhibit translocase I. |
| Organisms |
-Eubacteria |
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Family |
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| Links |
Enzyme (activities) mur24
BRENDA (activities) mur24
KEGG (pathways) mur24
PLPMDB (PLP mutants) mur24
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| References |
Cui Z, Overbay J, Wang X, Liu X, Zhang Y, Bhardwaj M, Lemke A, Wiegmann D, Niro G, Thorson JS, Ducho C, Van Lanen SG (2020) Pyridoxal-5'-phosphate-dependent Alkyl Transfer in Nucleoside Antibiotic Biosynthesis Nat Chem Biol in press. |
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| last changed |
2020/06/16 10:09 |
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