B6db activities : nikk

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	nikk
Description	Aminohexuronic acid aminotransferase (2.6.1.-)
Catalyzed reaction	Ketohexuronic acid + L-glutamate = aminohexuronic acid + 2-oxoglutarate
Cofactor	Pyridoxal phosphate
	The enzyme nikk is an essential protein for nikkomycin biosynthesis. Nikkomycins act as a competitive inhibitor of chitin synthetase and display potent activities against phytopathogenic and human pathogenic fungi.
Organisms	-Eubacteria
Family	nikk (0)

Links	Enzyme (activities) nikk BRENDA (activities) nikk KEGG (pathways) nikk PLPMDB (PLP mutants) nikk

References	Binter A, Oberdorfer G, Hofzumahaus S, Nerstheimer S, Altenbacher G, Gruber K, Macheroux P. (2011) Characterization of the PLP-dependent aminotransferase NikK from Streptomyces tendae and its putative role in nikkomycin biosynthesis. FEBS J 278 4122-35. Articles on nikk

last changed	2019/06/20 13:10

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