B6db activities : pctv

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	pctv
Description	3-aminobenzoate synthase (2.6.1.-)
Alternative names	3-aminobenzoic acid synthase; PctV (gene name); PtmT (gene name);
Catalyzed reaction	3-dehydroshikimate + L-glutamate = 3-aminobenzoate + 2-ketoglutarate + 2 H(2)O
Cofactor	Pyridoxal-phosphate.
	A PLP-dependent aminotransferase PctV, encoded in the pactamycin biosynthetic gene cluster, was found to catalyze the formation of 3-aminobenzoate from 3-dehydroshikimate with L-glutamate as the amino donor. The PctV reaction comprises a transamination and two dehydration reactions. This is the first report of a simple 3-ABA synthase in nature.
PDB	4ZM3;
Organisms	-Eubacteria
Family	pctv (0)

Links	Enzyme (activities) pctv BRENDA (activities) pctv KEGG (pathways) pctv PLPMDB (PLP mutants) pctv

References	Hirayama A, Miyanaga A, Kudo F, Eguchi T (2015) Mechanism-Based Trapping of the Quinonoid Intermediate by Using the K276R Mutant of PLP-Dependent 3-Aminobenzoate Synthase PctV in the Biosynthesis of Pactamycin Chembiochem 16 2484-90. Hirayama A, Eguchi T, Kudo F. (2013) A single PLP-dependent enzyme PctV catalyzes the transformation of 3-dehydroshikimate into 3-aminobenzoate in the biosynthesis of pactamycin. Chembiochem. 14 1198-203. Articles on pctv

last changed	2019/12/16 14:12

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