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pgat |
| Description |
Phenylglycine aminotransferase (2.6.1.-) |
| Alternative names |
L-phenylglycine transaminase.
PglE (gene name; ambiguous); |
| Catalyzed reaction |
phenylglyoxylate + L-tyrosine = L-phenylglycine + 4-hydroxyphenylpyruvate
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| Cofactor |
Pyridoxal-phosphate. |
| Comments |
L-Phe can also serve as the amino group donor (yielding phenylpyruvate as a product). |
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The enzyme from Streptomyces pristinaespiralis is involved in the biosynthesis of the antibiotic pristinamycin PI. |
| Organisms |
-Eubacteria |
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Family |
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| Links |
Enzyme (activities) pgat
BRENDA (activities) pgat
KEGG (pathways) pgat
PLPMDB (PLP mutants) pgat
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| References |
Osipenkov N, Kulik A, Mast YJ
(2018) Characterization of the phenylglycine aminotransferase PglE from Streptomyces pristinaespiralis J Biotechnol 278 34-38. Liu SP, Liu RX, El-Rotail AA, Ding ZY, Gu ZH, Zhang L, Shi GY
(2014) Heterologous pathway for the production of L-phenylglycine from glucose by E. coli J Biotechnol 186 91-7. Mast YJ, Wohlleben W, Schinko E.
(2011) Identification and functional characterization of phenylglycine biosynthetic genes involved in pristinamycin biosynthesis in Streptomyces pristinaespiralis J Biotechnol 155 63-7. |
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| last changed |
2018/05/14 09:45 |
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