B6db activities : tsra

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	tsra
Description	2-methyltriptophan aminotransferase (2.6.1.-)
Alternative names	TsrV
Catalyzed reaction	2-methyl-L-tryptophan + 2-oxoglutarate = 2-methyl-indole-pyruvate + L-glutamate
Cofactor	Pyridoxal-phosphate
Comments	The enzyme from Streptomyces laurentii is involved in thiostrepton biosynthesis. Other ketoacids, such as indolepyruvate or phenylpyruvate, can also serve as amino group acceptors.
Organisms	-Eubacteria
Family	tsra (0)

Links	Enzyme (activities) tsra BRENDA (activities) tsra KEGG (pathways) tsra PLPMDB (PLP mutants) tsra

References	Lin Z, Ji J, Zhou S, Zhang F, Wu J, Guo Y, Liu W (2017) Processing 2-Methyl-l-Tryptophan through Tandem Transamination and Selective Oxygenation Initiates Indole Ring Expansion in the Biosynthesis of Thiostrepton J Am Chem Soc 39 12105-12108. Kelly WL, Pan L, Li C. (2009) Thiostrepton biosynthesis: prototype for a new family of bacteriocins J Am Chem Soc 131 4327-34. Articles on tsra

last changed	2017/09/08 08:53

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