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ustd |
| Description |
Ustiloxin B synthase (4.2.1.-) |
| Alternative names |
UstD (gene name) |
| Catalyzed reaction |
L-aspartate + oxidized ustiloxin C = ustiloxin B + CO(2). |
| Cofactor |
Pyridoxal phosphate. |
| Comments |
Ustiloxins are post-translationally modified peptides (found in bacteria and fungi) that exhibit potent antimitotic activity and interfere with
microtubule assembly.
The UstD enzyme from Aspergillus flavus presumably catalyzes a beta-decarboxylation reaction on L-aspartate, followed by a substitution with the aldehyde form of ustiloxin C, to generate ustiloxin B.
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| Organisms |
-Fungi |
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Family |
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| Links |
Enzyme (activities) ustd
BRENDA (activities) ustd
KEGG (pathways) ustd
PLPMDB (PLP mutants) ustd
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| References |
Ye Y, Minami A, Igarashi Y, Izumikawa M, Umemura M, Nagano N, Machida M, Kawahara T, Shin-Ya K, Gomi K, Oikawa H. (2016) Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post‐translationally Modified Peptide Ustiloxin B in Filamentous Fungi Angew Chem Int Ed Engl 55 8072-5. |
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| last changed |
2018/11/21 10:20 |
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