type	Journal Article
authors	Li, G.; Foote, C.; Alexander, S.; Alexander, H.
title	Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum
journal	Development
Activity	4.1.2.27
Family	4.1.2.27
sel	selected
ui	11566853
year	(2001)
volume	128
number	18
pages	3473-83
keywords	Aldehyde-Lyases/genetics/*physiology
abstract	Sphingosine-1-phosphate, a product of sphingomyelin degradation, is an important element of signal transduction pathways that regulate cell proliferation and cell death. We have demonstrated additional roles for sphingosine-1-phosphate in growth and multicellular development. The specific disruption in Dictyostelium discoideum of the sphingosine-1-phosphate lyase gene, which encodes the enzyme that catalyzes sphingosine-1-phosphate degradation, results in a mutant strain with aberrant morphogenesis, as well as an increase in viability during stationary phase. The absence of sphingosine-1-phosphate lyase affects multiple stages throughout development, including the cytoskeletal architecture of aggregating cells, the ability to form migrating slugs, and the control of cell type-specific gene expression and terminal spore differentiation. This pleiotropic effect, which is due to the loss of sphingosine-1-phosphate lyase, establishes sphingolipids as pivotal regulatory molecules in a wide range of processes in multicellular development.
last changed	2009/06/23 09:14