type	Journal Article
authors	Shinohara Y, Kudo F, Eguchi T.
title	A natural protecting group strategy to carry an amino acid starter unit in the biosynthesis of macrolactam polyketide antibiotics
journal	J Am Chem Soc.
Activity	vino
Family	vino
sel	selected
ui	22010945
year	(2011)
volume	133
number	45
pages	18134-7
keywords	doi: 10.1021/ja208927r
abstract	Macrolactam antibiotics are an important class of macrocyclic polyketides that contain a unique nitrogen-containing starter unit. In the present study, a set of starter biosynthetic enzymes in the macrolactam antibiotic vicenistatin was characterized. We found that the protection-deprotection strategy of the aminoacyl-ACP intermediate was critical in this system. On the basis of bioinformatics, the described pathway is also proposed as a common method for carrying amino acids in the biosynthesis of other macrolactam antibiotics.
last changed	2018/11/14 08:49