type	Journal Article
authors	Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Roth M, Brakhage AA, Hertweck C.
title	Epidithiol formation by an unprecedented twin carbon-sulfur lyase in the gliotoxin pathway.
journal	Angew Chem Int Ed Engl
Activity	glii
Family	glii
sel	selected
ui	22936680
year	(2012)
volume	51
number	40
pages	10064-8
abstract	The elucidation of a key step in the biosynthesis of gliotoxin, the infamous virulence factor of the human pathogen Aspergillus fumigatus, provides insight into the formation of an epidithiol. Isolation of a bis(cysteine) S-conjugate from a ΔgliI mutant and in vitro studies show that GliI concomitantly cleaves two C[BOND]S bonds, along with the formation of ammonia and pyruvate
last changed	2014/08/22 09:44