type	Journal Article
authors	Funabashi M, Baba S, Takatsu T, Kizuka M, Ohata Y, Tanaka M, Nonaka K, Spork AP, Ducho C, Chen WC, Van Lanen SG
title	Structure-based gene targeting discovery of sphaerimicin, a bacterial translocase I inhibitor
journal	Angew Chem Int Ed Engl
Activity	lipk
Family	lipk
sel	selected
ui	24014169
year	(2013)
volume	52
number	44
pages	11607-11
keywords	actinomycetes; bacterial translocase I inhibitor; gene targeting; nucleoside antibiotics; transaldolase
abstract	Rise and shine: Using a gene-targeting approach aimed at identifying potential L-threonine:uridine-5'-transaldolases that catalyze the formation of (5'S,6'S)-C-glycyluridine, a new bacterial translocase I inhibitor was discovered from an actinomycete following fermentation optimization.
last changed	2018/11/07 13:28