type	Journal Article
authors	Ichinose, H.; Kurosawa, Y.; Titani, K.; Fujita, K.; Nagatsu, T.
title	Isolation and characterization of a cDNA clone encoding human aromatic L-amino acid decarboxylase
journal	Biochem Biophys Res Commun
Activity	4.1.1.28
Family	4.1.1.28
sel	selected
ui	2590185
year	(1989)
volume	164
number	3
pages	1024-30
keywords	Adrenal Gland Neoplasms/*enzymology/genetics
abstract	The nucleotide sequence of a cDNA clone that includes the entire coding region of human aromatic L-amino acid decarboxylase gene is presented. A human pheochromocytoma cDNA library was screened using an oligonucleotide probe which corresponded to a partial amino acid sequence of the enzyme purified from the human pheochromocytoma. The isolated cDNA clone encoded a protein of 480 amino acids with a calculated molecular mass of 53.9 kDa. The amino acid sequence Asn-Phe- Asn-Pro-His-Lys-Trp around a possible cofactor (pyridoxal phosphate) binding site is identical in human, Drosophila, and pig enzymes.
last changed	2009/06/12 11:42