type	Journal Article
authors	Gonzalez-Porque, P.; Strominger, J.L.
title	Introducting of the 3-deoxy group in 3,6-dideoxyhexoses: a novel cofactor function for pyridoxamine-5'-phosphate
journal	Proc Natl Acad Sci U S A
Activity	1.17.1.1
sel	selected
ui	4504380
year	(1972)
volume	69
number	6
pages	1625-8
abstract	A cofactor needed for the reduction of CDP-4-keto-6-deoxy-D-glucose to CDP-4-keto-3,6-dideoxy D-glucose has been detected and purified. Its spectra in neutral, acid, and basic solutions, its behavior on thin-layer chromatography, and other properties led to its identification as pyridoxamine-5′-phosphate. Moreover, authentic pyridoxamine-5′-phosphate substituted for the purified cofactor with about the same specific activity. Other vitamin B6 derivatives did not stimulate the reaction, and inhibition was observed with some of them.
last changed	2009/05/05 11:54